photo of student with pony  

Cornell Ruffian Equine Specialists

Alan J. Nixon

Alan J. Nixon
Cornell University
College of Veterinary Medicine
C3 187 VMC, Box 32
Ithaca, NY 14853

Selected Publications

Wilke MM, Nydam DV, Nixon AJ. Enhanced early chondrogenesis in articular defects following arthroscopic mesenchymal stem cell implantation in an equine model. J Orthop Res 25:913-925, 2007.

Goodrich LR, Nixon AJ. Genetic modification of chondrocytes with insulin-like growth factor enhances cartilage healing in an equine model. J Bone Joint Surg, Br 89:672-685, 2007.

Morisset S, Frisbie DD, Robbins PD, Nixon AJ, McIlwraith CW. IL-1ra/IGF-1 gene therapy modulates repair of microfractured chondral defects. Clin Orthop Relat Res 462:221-228, 2007.

Nixon AJ, Goodrich LR, Scimeca MS, Witte TH, Schnabel LV, Watts AE, Robbins PD. Gene therapy in musculoskeletal repair. Ann NY Acad Sci 1117:310-327, 2007.

Zaidi N, Nixon AJ. Stem cell therapy in bone repair and regeneration. Ann NY Acad Sci 1117:62-72 2007.

Gratz KR, Wong VW, Chen AC, Fortier LA, Nixon AJ, Sah RL. Biomechanical assessment of tissue retrieved after in vivo cartilage defect repair: tensile modulus of repair tissue and integration with host cartilage. J Biomech 39:138-146, 2006.

Goodrich LR, Nixon AJ. Medical treatment of osteoarthritis in the horse - A review. Vet J 171:51-69, 2006.

Dahlgren LA, Mohammed HO, Nixon AJ. Expression of insulin-like growth factor binding proteins in healing tendon lesions. J Orthop Res 24:183-192, 2006.

Goodrich LR, Brower-Toland BD, Warnick L, Robbins PD, Evans CH, Nixon AJ. Direct adenovirus-mediated IGF-I gene transduction of synovium induces persisting synovial fluid IGF-I ligand elevations. Gene Ther 13:1253-1262, 2006; Epub 2006 May 18.

Semevolos SA, Nixon AJ, Fortier LA, Strassheim ML, Haupt J. Age-related expression of molecular regulators of hypertrophy and maturation in articular cartilage. J Orthop Res 24:1773-1781, 2006.

Donnelly BP, Nixon AJ, Haupt JL, Dahlgren LA. Nucleotide structure of equine platelet-derived growth factor-A and -B and expression in horses with induced acute tendinitis. Am J Vet Res 67:1218-1225; Erratum in 67:1627, 2006.

Haupt JL, Donnelly BP, Nixon AJ. Effects of platelet-derived growth factor-BB on the metabolic function and morphologic features of equine tendon in explant culture. Am J Vet Res 67:1595-1600, 2006.

Watts AE, Nixon AJ. Comparison of arthroscopic approaches and accessible anatomic structures during arthroscopy of the caudal pouches of equine femorotibial joints. Vet Surg 35:219-226, 2006.

Cheetham J, Nixon AJ. Arthroscopic approaches to the palmar aspect of the equine carpus. Vet Surg 35:227-231; Erratum in 35:412, 2006.

Fealy S, Rodeo SA, MacGillivray JD, Nixon AJ, Adler RS, Warren RF. Biomechanical evaluation of the relation between number of suture anchors and strength of the bone-tendon interface of a goat rotator cuff model. Arthroscopy 22:595-602, 2006.

MacGillivray JD, Fealy S, Terry MA, Koh JL, Nixon AJ, Warren RF. Biomechanical evaluation of a rotator cuff defect model augmented with a bioresorbable scaffold in goats. J Shoulder Elbow Surg 15:639-644, 2006.

Strauss EJ, Goodrich LR, Chen CT, Hidaka C, Nixon AJ. Biochemical and biomechanical properties of lesion and adjacent articular cartilage after chondral defect repair in an equine model. Am J Sports Med 33:1647-1653, 2005.

Semevolos SA, Strassheim ML, Haupt JL, Nixon AJ. Expression patterns of hedgehog signaling peptides in naturally acquired equine osteochondrosis. J Orthop Res 23:1152-1159, 2005.

Beinlich CP, Nixon AJ. Prevalence and response to surgical treatment of lateral palmar intercarpal ligament avulsion in horses: 37 cases (1990-2001). J Am Vet Med Assoc 226:760-766, 2005.

van Weeren PR, Nixon AJ. Closing in on the equine joint. Equine Vet J 37:493-494, 2005.

Nixon AJ, Haupt JL, Frisbie DD Morisset SS, McIlwraith CW, Robbins PD, Evans CH, Ghivizzani S. Gene-mediated restoration of cartilage matrix by combination insulin-like growth factor-I/interleukin-1 receptor antagonist therapy. Gene Ther 12:177-186, 2005.

Fortier LA, Nixon AJ. New surgical treatments for osteochondritis dissecans and subchondral bone cysts. Vet Clin North Am Equine Pract 21:673-690, 2005, vii. Review.

Dahlgren, LA, Nixon AJ. Cloning and expression of equine insulin-like growth factor binding proteins in normal equine tendon. Am J Vet Res 66:300-306, 2005.

Dahlgren LA, Mohammed HO, Nixon AJ. Temporal expression of growth factors and matrix molecules in healing tendon lesions. J Orthop Res 23:84-92, 2005.

Haupt JL, Frisbie DD, McIlwraith CW, Robbins PD, Ghivizzani S, Evans CH, Nixon AJ. Dual transduction of insulin-like growth factor-I and interleukin-I receptor antagonist protein controls cartilage degradation in an osteoarthritic culture model. J Orthop Res 23:118-126, 2005.

Nixon AJ, Schachter BL, Pool RR. Exostoses of the caudal perimeter of the radial physis as a cause of carpal synovial sheath tenosynovitis and lameness in horses: 10 cases (1999-2003). J Am Vet Med Assoc 224:264-270, 2004.

Nixon AJ, Fortier LA, Goodrich LR, Ducharme NG. Arthroscopic reattachment of osteochondritis dissecans lesions using resorbable polydioxanone pins. Equine Vet J 36:376-383, 2004.

Trippel SB, Ghivizzani SC, Nixon AJ. Gene-based approaches for the repair of articular cartilage. Gene Ther 11:351-359, 2004.

Beinlich CP, Nixon AJ. Radiographic and pathologic characterization of lateral palmar intercarpal ligament avulsion fractures in the horse. Vet Radiol Ultrasound 45:532-537, 2004.

Goodrich LR, Nixon AJ. Treatment options for osteomyelitis. Equine Vet Educ 16:267-280, 2004.

Hidaka C, Goodrich LR, Chen C-T, Warren RF, Crystal RG, Nixon AJ. Acceleration of cartilage repair by genetically modified chondrocytes over expressing bone morphogenetic protein-7. J Orthop Res 21:573-583, 2003.

Fortier LA, Mohammed HO, Lust G, Nixon AJ. Insulin-like growth factor-I enhances cell-based repair of articular cartilage. J Bone Joint Surg Br 84:276-288, 2002.

Semevolos S, Brower-Toland BD, Bent S, Nixon AJ. Parathyroid hormone-related peptide and Indian hedgehog expression patterns in naturally acquired equine osteochondrosis. J Orthop Res 20:1290-1297, 2002.


Nixon AJ. Equine Fracture Repair, Philadelphia, PA, WB Saunders, 1996. Contributing author and editor.

McIlwraith CW, Nixon AJ, Wright IA, Boening J. Diagnostic and Surgical Arthroscopy in the Horse, 3rd edition, London, UK, Harcourt, 2004. Coauthor.